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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

Since then, Teach First has put 5,000 graduates into schools, working with more than 1m pupils in low-income areas, helping to raise standards in classrooms, particularly London.
4.无人驾驶的汽车

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
From the themed collection: 北京二手房成交量连跌俩月
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

The report also showed regions with a better-developed economy produce more cyberstars, with Beijing, Shanghai, Guangdong, Jiangsu and Zhejiang leading the rankings.
The Amsterdam crisis began when a Dutch group known as the Seppenwolde syndicate made a big, contrarian bet on the shares of East India Company. Those shares had plunged in 1771 mainly because of losses in Bengal, but the company kept paying high dividends and covered up its shortfalls by borrowing money. Convinced that East India shares would quickly rebound, the Seppenwolde group aggressively bought them on margin. But instead of rebounding, the shares fell even further after the company slashed its dividend.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

From the themed collection: 三大因素导致水泥行业产能过剩
Open Access Perspective

Soft matter science and the COVID-19 pandemic

这些,都只是纽约人2015年将会遇到的部分问题。而且,邻居家的儿子在圣诞节收到了新的爵士鼓,你又免不了要头疼了……

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

Ferreira added that while the entire Brazilian population has suffered during preparations for the World Cup, mostly because of big construction projects that have snarled traffic and extended already long commutes for the poor who live on the outskirts of cities, she feels like only the rich are reaping the benefits of the real World Cup experience.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
From the themed collection: 阎焱辞任雷士照明董事长
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

指数: 97.8
Epic Games游戏工作室对包括迦勒·罗杰斯在内的两个人进行了法律诉讼,因为他们使用作弊软件来玩《堡垒之夜》这个游戏。
?备用发电机的失败使得纽约大学医院分部的Langone医学中心被迫撤离。大约200名病人被迫转移。官员们正在调查备用电源失败的原因。
我们不会越俎代庖,不会超越区域去做不应是中国做的事情。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
From the themed collection: 减税得实惠 调控不放松
Perspective

Trends and targets in antiviral phototherapy

Meanwhile, he was being ferried around the globe to tech conferences, getting introduced to other potential investors. D'Aloisio made a remarkable impression on everyone he crossed paths with. 'He has an eerie maturity,' says Andrew Halls, headmaster of the King's College School in Wimbledon, which D'Aloisio has attended since he was 11. 'He has an extraordinary articulateness in the face of situations that, for me, even as a 54-year-old, might be terrifying.'
Will the Saudi Aramco public offering debut on an international market
With an increase of 7 percent over 2013,total spending on medicines will amount to $1.06trillion in 2014, says the report"The Global Use of Medicines: Outlook through2018" from the IMS Institute for Healthcare Informatics, releasedThursday.
But we are going to get a taste of the new world order when the WTO’s members gather for its biennial ministerial in Buenos Aires in December. It’s unclear, as always, if the WTO will be able to deliver anything of substance. But the real test lies in not having the US leading the way in discussions for the first time in the WTO’s life. Will China step in? The EU? And will India be as minded to block any deal as it has been in the past?

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

n. 批准,认可,同意,赞同

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

['?:b?n]

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

Track field;hand ball;cycling;track racin;racing cycle;mountain bike race;Bicycle Motocross;horsemanship;football;Beach Volleyball.
金球奖的独特之处在于其同时设置电影和电视奖项。而当地时间周日的这场典礼更是前所未有地模糊了二者的界限,大大褒奖了电视领域这一年来的出众表现。现已剧终的热门电视剧集《绝命毒师》(Breaking Bad)今年首次拿下金球奖,赢得了当晚最热烈的欢呼声。该片荣获剧情类最佳系列剧集奖,片中演员布赖恩?克兰斯顿(Bryan Cranston)荣获剧情类系列剧最佳男演员。

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

Mr Erdogan’s escalation comes in the midst of a vitriolic tit-for-tat between Ankara and The Hague, which began at the weekend after Dutch officials barred Turkish ministers from campaigning in Turkish communities inside the Netherlands.
你要去里约看奥运会吗?你会在安卓或者iOS上装谷歌地图这个应用软件吗?我想你已经有了答案了。

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
From the themed collection: 东莞家具业老板跑路成风
Open Access Review Article

Diagnostic technologies for COVID-19: a review

Busting through the glass ceiling
AT&T和时代华纳(Time Warner)会在不作出大的妥协(比如出售美国有线新闻网(CNN))的情况下完成合并吗?

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

Iron ore imports fell 12.3 per cent by volume in October from the previous month and 4.9 per cent from the same month a year earlier while coal imports were down 21.4 per cent from September and 30.7 per cent from a year earlier, according to Chinese customs data.
Essentially this reform will help the government to focus on performing its due role more effectively instead of overreaching itself, because that will only tie down our businesses, cut government’s efficiencies and even public credibility.
The 2013 World Happiness Report comes on the back of a growing global movement calling for governments and policy makers to reduce their emphasis on achieving economic growth and focus on policies that can improve people's overall well-being.
伦敦——自2002年开设以来,“周六人物”(Saturday Profile)便旨在向《纽约时报》的读者介绍世界各地的人。读者可能从来没有听说过这些人,但他们过着有趣的生活,做过不同寻常的事情,或者刚刚有了一段非凡的经历。

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

5. 杜克大学福库商学院

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

Please accept our wishes for you and yours for a happy New Year.
3=有时是

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

北京某投资公司总经理汪杰表示,金融和地产业高管较高的薪酬反映出我国发展不平衡的问题。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
From the themed collection: 高端光伏幕墙钱景可期
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

挪威诺贝尔和平奖委员会主席亚格兰赞扬这三位女士的成就,还说,除非女性享有和男性一样的机会,否则我们不能实现持久的和平。

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

她向BBC透露称:“他们看到了一些非常可怕的事情,但是他们将在很长一段时间内继续接触这类事情。”
如果计划生育法修正草案在星期日被中国最高立法机关批准,全面二孩政策的实施将不再会有任何法律障碍。
有些腐烂的鸡爪竟然出产于1967年,在腥臭扑鼻的处理场里,这些鸡爪经过漂白剂和其它化学物质“清洁”、涨泡、漂白流程之后,便可重新上市出售。
She added that because of economic conditions and anti-immigration sentiment in some Western countries, many Chinese students find it difficult to stay in those countries.

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

项目长度:22个月
威廉姆斯指出,来自巴西、越南、台湾和智利的11月初数据表明,出口形势自10月以来持续改善。
The People’s Bank of China has long intervened in foreign-exchange markets to hedge against excessive volatility. Since August, however, such intervention has expanded from the domestic spot market, which covers daily transactions, to include the offshore renminbi market in Hong Kong, as well as both onshore and offshore futures markets, traders say.
英国会是七国集团(G7)中经济增长最慢的国家吗?
enter在中间+tain拿住+ment→在[工作]中间拿→娱乐,款待

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

域名注册公司GoDaddy的总部设在亚利桑那州斯科茨代尔市,该公司5月份在坦佩开工建设新的全球技术中心。GoDaddy公司已经在大凤凰城地区雇佣了2,600名员工,新工厂预计将增加300多个工作岗位。其他在亚利桑那州扩大规模的公司包括领先的技术保障服务公司 Asurion。这家公司在凤凰城开设了新的技术支持中心,将在今年年底招聘500多个职位。能源供应商Direct Energy今年在亚利桑那州坦佩开设了新的呼叫中心,需要招聘300多名员工。
Judge Business School at the University of Cambridge jumps five places to fifth. Not only is it the first time it has broken into the top five, but it is also the first occasion that LBS is not the top-placed UK school in the MBA ranking.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

petroleum

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

201012/119869.shtml重点单词

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

在岛上海边的总督大楼,数万名支持群众等待罗塞略在宣誓就职典礼后的到来,手握着伞挡住炽热阳光。
德系三巨头:由于奔驰的几款低价产品不可避免地会损害它“要么最好,要么什么都不是”(the best or nothing)的商誉,该公司也开始陷入低迷。而即将推出的新7系轿车则会进一步巩固宝马在美国富人圈中的地位。另外,起价30,795美元的奥迪A3,很可能会使奥迪的销量较2014年增长15%,新款Q7也将进一步提高奥迪的利润。
Alice Schwarzer, who has battled for women’s rights for years, is stunned that “an old-school sexist” like Donald J. Trump could win the United States presidency.
这份榜单的四所英国大学分别是剑桥大学、牛津大学和伦敦大学和帝国理工学院。东京大学也位列前20名。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

The best of 2015
据报道,香奈儿艺术总监卡尔·拉格菲尔德于巴黎去世,享年85岁,整个时尚界都为他的离世而感到震惊。
Local residents living near the launch sites have complained that the activists are putting their lives at risk by making them potential targets for North Korean retaliation.
Mr Mallaby accepted the award at a dinner in London on November 22, where the guest speaker was Dido Harding, chief executive of TalkTalk, the UK telecoms group.

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

While the debate was supposed to be solely about foreign policy, domestic concerns were never far from the surface and the candidates took every opportunity to pivot to their stump speech attacks over the economy and tax. The same was true in the spin room afterwards where both campaign teams dispensed quickly with debate comments and moved instead to analysis of the state of the race in swing states.
These documentaries use the standard tools — archival footage, talking-head interviews, carefully selected musical cues — to write history in the present tense. In the era of Black Lives Matter, the stories of the Black Panthers and the jazz singer and activist Nina Simone could hardly be more relevant. Mr. Nelson and Ms. Garbus tell them beautifully.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

As fall arrived and school began, D'Aloisio felt immense pressure to deliver for his backers. He needed to whip his algorithm into better shape, so he contracted a team of Israeli coders who specialize in natural language processing. Searching on Google, he found and hired a retired professor living in Thailand who'd written seminal books on the topic. 'He became our main scientist,' says D'Aloisio. 'He now works at Yahoo! in the Sunnyvale office.'
在交易截止日到来前,看清楚他们会往哪个方向走这件事将会十分有趣。他们有很多靠得住的球员团结在布鲁克-洛佩兹身边。
在9月初发布的另一份报告中,世界气象组织(World Meteorological Organization)称,2013年大气中的二氧化碳水平,比工业革命之前的普遍水平高出42%。其他重要的温室气体含量也有所增加,与前工业化时代水平相比,甲烷增加了153%,一氧化二氮增加了21%。
Barack Obama went on the offensive over foreign policy in the third and final presidential debate, repeatedly accusing Mitt Romney of flip-flopping on major international issues but failing to deliver a killer blow to his opponent's resurgent campaign.
最佳豪华汽车品牌:保时捷

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

The 5.5-percent increase this year is reasonable given a less anticipated consumer price index (CPI) as well as slower salary and GDP growth, said Jin Weigang, head of the social security research institute under the MOHRSS.
n. 舞厅
n. 社交聚会

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

Wishing you peace, joy and happiness through the coming year.在新年来临之际,祝福你平安、快乐、幸福!
It seems that Christmas time is here once again, and it is time again to bring in the New Year. We wish the merriest of Christmas to you and your loved ones, and we wish you happiness and prosperity in the year ahead.又该迎接新的一年了。我们向你及你的亲人们致以最美好的祝福,愿你在新的一年里事业兴旺,幸福美满!

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
From the themed collection: 数据向好难挡楼市调控加码
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

中国力争达成自己的亚太区协议
This includes McKinsey, the consultancy that kick-started its secretive leadership election process in October with a gathering of more than 500 senior partners at the Grosvenor House Hotel in London. The next stage involves the firm’s 550 senior partners voting on a shortlist of candidates to replace Dominic Barton — the incumbent since 2009 — in January, followed by a run-off between the two most popular candidates in February.
达洛伊西奥常喜欢说“时间是新的货币”。这是一个17岁男孩对人生的睿智洞察,也是Summly软件背后的发展理念。而我们多数人在他那个年龄,时间多得都不知道该怎么做才不会荒废。我很容易就忘了这样一个事实:达洛伊西奥在1995年出生于一个中上层阶级家庭,连高中都还没毕业,还住在小时候住的那个舒服卧室里。在我和他父母聊天的时候,他离开房间去在电脑上干活。只见他穿着袜子下楼,牛仔裤腿扫过大厅的地毯──此时此刻是他最像个孩子的时候。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

到现在第22部007系列片已经登场,邦女郎角色变迁,不过有一点我们可以肯定,无论007电影怎么拍,邦女郎总会漂亮性感、聪明高贵而且越来越有内涵。这是007电影过去、现在乃
伯利兹城最富盛名的旅游胜地莫过于巨大的水下天坑--蓝色巨洞以及玛雅遗址。
Shipments to China cratered by 14.4 per cent year-on-year to Rmb737.5bn in January. That’s from a 4 per cent drop in December, and versus expectations for a 1.8 per cent rise.

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

律师本质上是谨慎的,但他们中的大多数人已经认识到,技术是处理他们需要梳理的大量信息的关键。没有技术,披露和合规等一些需要处理很多文件的工作几乎不可能完成。

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

在过去的二十年里,几起校园中毒事件引发了群众对学生心理发展及帮助的争论和关注。

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

据国家新闻出版广电总局介绍,自2003年以来,中国这一世界第二大电影市场的票房总额平均逐年增长35%。仅仅在2015年,这一数字就猛增了48.7%。
In October last year North Korean border guards attempted to shoot down some balloons, triggering a brief exchange of heavy machine-gun fire between the two sides.

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

再来看一下流失顾客的公司吧。
在根据真实罪案改编的电影《狐狸猎手》(Foxcatcher)中,以出演喜剧闻名的演员史蒂夫·卡瑞尔(Steve Carell)饰演大富翁约翰·E·杜邦(John E. du Pont)时隐藏在假面具后面。这个造型最突出的就是鸟嘴状鼻子。
译文属可可原创,仅供学习交流使用,未经许可请勿转载
评委会将奖项授予了来自东京工业大学的大隅良典,以表彰他在细胞自噬作用研究上所做的贡献。

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

5. Bank of America Corp.
A savings account had been opened in the boy's name and he used those details when signing up for AdWords.

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
From the themed collection: 建陶业盼借政策东风健康发展
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

This year, the Global 2000 companies hail from 62 countries, up from 46 in our inaugural 2003 ranking. In total, they raked in revenues of $38 trillion and profits of $3 trillion, with assets worth $161 trillion and a market value of $44 trillion.
['letis]

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

The commerce ministry data showing plummeting real estate investment follows an overall 53 per cent rise last year to a record $33bn, according to separate data from JLL, a global realtor.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
From the themed collection: 木地板行业 如何打造品牌差异化?
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

Next year, the mayor’s affordable housing plan, which calls for building or preserving 200,000 units of affordable housing over the next decade, will begin to take shape. It hinges on a policy that requires developers to build affordable housing in exchange for being allowed to construct taller and denser buildings in neighborhoods rezoned by the city. Developers and housing advocates alike are waiting to see what it will look like once the administration adds muscle and flesh to the bones of the proposal.
During last year's LFW, there were 250 anti-fur protesters, The Guardian reported, and a show in February saw an activist storm the stage at a Mary Katrantzou show.
A cemetery dating back roughly 1,700 yearshas been discovered along part of the Silk Road, a series of ancient trade routes that once connected China to the Roman Empire.
电池电力可能最终被证明是一种过渡性技术。最近电池成本的降低速度已经放慢了,特斯拉曾经承诺要在2017年生产出价格在35,000美元左右的Model 3。要实现这个目标,特斯拉的电池成本需要下降30%。相比之下,丰田(Toyota)最近的举动非常出人意料。它与特斯拉签订的电池供应协议即将期满,但丰田并未续约,而是准备加倍投入研发氢燃料电池。燃料电池的成本下降速度要快于普通电池。而且燃料电池的拥趸们认为,车主肯定会更喜欢充电速度相对更快的燃料电池,而不是要为充电等上好几个小时。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

5. The causes of hair loss and greying are linked, and for the first time, scientists have identified the cells responsible.
con共同,sci知道,ious多:什么都知道-清醒

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

As a result, business investment in key areas such as equipment has been historically weak for a U.S. recovery. A slowly improving jobs picture and rising household wealth could spark a virtuous cycle of stronger consumer spending, increased business confidence and rising investment. If it doesn't, the year could be another letdown.
此次涵盖95个项目(去年为90个)的排行榜中,来自7个国家的9所院校为首次进入榜单。排名第41位的法兰克福金融管理学院(Frankfurt School of Finance & Management)是今年排名最高的新入榜者。这家德国学院拥有性别比例最平衡的项目之一,女性占学员总数的49%。
这是两部后自语核(post-mumblecore)喜剧,讲述自我认知及其边界的故事。布西内斯克的影片是完美的怪人三角,三条边分别是盖·皮尔斯(Guy Pearce)、寇碧·史莫德斯(Cobie Smulders)和凯文·科利根(Kevin Corrigan),以德克萨斯州奥斯汀怪人们轻松胡混的伪装出现。皮文的影片探索精神病以及日间电视节目的的黑暗疆域。由于克里斯汀·韦格(Kristen Wiig)的精彩演出(她饰演一个名叫爱丽丝·克里格的彩票得主),《欢迎来到我的世界》成了关于美国梦想者的精彩肖像,既令人不安,也鼓舞人心。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

5. It's a dog's life for the British
公司:网络投票公司Everyone Counts
准备接收附近酒吧发布的微博广告吧

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

Song of the year: "Over you," Miranda Lambert and Blake Shelton
然而,在毕业3年后,担任部门负责人或以上级别职位的女性(59%)显著少于男性(68%)。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
From the themed collection: 小区业主卖房时联合涨价是否违法
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
From the themed collection: 陶瓷企业与供应商“智斗”内幕
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

200911/88512.shtmlA love letter to a US college student from the girlfriend who was to become his wife is finally on its way to him - 53 years after it was written in 1958.
另一个会造成失业的常见的习惯就是过度沉溺于社交媒体。有些公司采取了相应的措施来监控或限制员工使用社交媒体。有些公司甚至完全屏蔽掉这些网站。所以注意了花太多的时间在社交媒体或者与工作无关的网站上可能会让你饭碗不保哦!
31岁的扎克伯格去年的表现力压群豪,个人资产上涨了112亿美元,从去年的第十六位跃升至今年的第六位。这是他和杰夫·贝佐斯首次进入福布斯年度排名榜单前十位。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

Yes, 2014 is an absolute total disaster just waiting to ignite. In 'Doomsday poll: 87% risk of stock crash by year-end' we analyzed 10 major crash warnings since early this year. Since then, more incoming bogies raced across our radar screen. Ticking time bombs from Congress, the Supreme Court, sex, carbon emissions, Big Oil, NSA, IRS, Tea Party austerity. Relentless. Mind-numbing.
现在达洛伊西奥还不负责管理他的收入。他坚称说,我太年轻了,还不懂如何发挥其价值。我没有房贷,我才17。对我来说100英镑就是个大数目了,这就是我对钱的大致概念。尽管他无法对Summly的售价置评,但当我逼问他未来打算如何支配的时候,他说他在考虑以后也许可以用所发之财来做一名天使投资人。在他身边,似乎没人觉得这份钱会毁掉他或者他会挥霍钱财浪费人生。戴安娜说,孩子很踏实,很有冲劲儿,他不会停止奋斗的。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
From the themed collection: 家居企业的维权之殇
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

华盛顿:到十月份底,印度减持美国政府债券到775亿美元,尽管作为世界上最大经济体的美国的经济在稳步的上升。
Some 88 Chinese universities are included in the Global 400 subjects in the latest QS World University Rankings by Subject, which was released Tuesday by QS Quacquarelli Symonds, a higher education research firm.
slouch

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

课程安排:周五周六交替上课,入学伊始学员需参加一个为期一周的会议,还有一个为期一周的国际学习研讨会

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
From the themed collection: 智能家居领域的三种生存模式
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

一家非官方机构出具的中国制造业衡量指标在11月下降,表明国有企业的业务增长并未扩展到规模较小和私营的工厂。
Besides exploring the overall ranking, prospective international students can narrow their search by browsing regional and country rankings. These rankings were determined solely by how schools performed in the overall list.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
From the themed collection: 北京市家具以旧换新重启临近
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

Whether China opens the stock floodgates or not will be a major price-driver in cotton and sugar — and potentially also in corn, soyabean or vegetable oil — markets in 2017, the bank said in its report.
3.你老板从他认识的人那收到了你认识的人给的简历。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

北京2016年受理外籍人士及其家属永久居留申请较2015年增长426%。
学员平均年龄:36岁(英语授课项目)

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
From the themed collection: 大湾区概念之下楼市如何走?
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

准时完成你的工作。即使还有额外的任务,也要如此。
And, this year, Star Wars found its way onto the list as well, with ‘starwars’ claiming the 16th spot.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

unemployment

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
From the themed collection: 杭州家居行业拐点来了
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

Then there were these cautionary tales, where a candidate
Song “Happiness” (Mao A’Min)
PPI已连续下降44个月,反映出建房材料和原料的供应过剩,以及重工业的产能过剩。
n. 平台,站台,月台,讲台,(政党的)政纲

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

或许你会认为这个60%并不起眼,但它是很重要的一步,因为在2003年,同性婚姻在美国的任何地方都是不合法的。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
From the themed collection: 长租品牌公寓成为租客新宠
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

Helsinki-based developer Remedy Entertainment has blurred the line between Hollywood and games with previous incarnations Max Payne and Alan Wake. Now the studio is combining next-generation visuals with the tension and drama of scripted television. Set in the university town of Riverport, Quantum Break puts players in control of Jack Joyce and Beth Wilder, a pair of ordinary people who are given the extraordinary power to manipulate time after an accident that creates a time rift. Time will randomly break down during the game, which causes disasters in the environment that pause, stutter, rewind and freeze. Fans of Max Payne’s bullet time will see new strategies emerge with gunfights involving time-amplified combat as the player fights against the Monarch Corporation. In addition to the virtual storyline, the game features custom live action storytelling that’s personalized based on the decisions one makes.
How do you feel about workingwith Ei Aoki again in Aldnoah?
The Big Bang Theory is not short on geniuses. Not only is the show about highly intelligent scientists, but cast member Mayim Bialik has a Ph.D. in Neuroscience. So it should come as no surprise that the cast would want to show off their intelligence and attention to detail. In Sheldon and Leonard's apartment, there's a large white board. The two roommates use the board frequently for everything from actual work that Leonard or Sheldon has brought home, or to decide whether to eat before or after the new Spider-Man movie.

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

现在,Swyft一半的收入都来自于为格温o史蒂芬尼制作的这类广告。雷表示,Swyft每月收入的增长幅度在50% 到100%之间。另一半就来自销售贴纸——主要是靠知名运动队和《怪物史莱克》这样的娱乐品牌授权。
指尖陀螺

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
From the themed collection: 新广告法 让行业竞争更规范
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

6.London's bike hire scheme couldn't be simpler, by the way: just go up to the terminal at any docking station, pay by card and take away one of our so-called "Boris bikes". When you're done with it, simply throw it into the nearest canal. They're disposable!
adj. 忙碌的,使用中的,订婚了的

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

10月份,美国联邦政府停止运转。星巴克CEO霍华德舒尔茨拒绝在所有公司都受到不利影响时袖手旁观。他写了一封请愿书,号召各公司CEO上街游行,给国会施加压力,迫使后者通过预算案。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

审校:赵倩 来源:前十网
乔斯的母亲因玛·克萨达在接受《西班牙日报》采访时表示,她的儿子想要给自己的乐队“Los Salerosos”(大意为“冒失鬼”)购买乐器。他在乐队里担任小号手。
Citing recent figures from the CPB Netherlands Bureau for Policy Analysis, that show global trade in seasonally-adjusted volume terms fell 1.1 per cent between September and October, Mr Leering suggests last year will prove to be the worst year for world trade since 2009.

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

Thirty Seconds of Mars, who are fronted by American actor Jared Leto, took home the Best Alternative award, which also saw Lana Del Rey, Lorde, The XX and Imagine.
这张专辑等于是一次直截了当的暗示,提醒着我们,不论什么时候,只要霉女王想要,她就能拿回自己在流行音乐界的领先地位。
而中国工商银行排在榜单的第十位,是该榜单上排名最高的中国企业。
original

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

Overall twenty-eight thousand bombs and other munitions were exploded over Yugoslavia a country the size of Ohio. William Cohen then secretary of defense characterized Allied Force as “the most precise application of airpower in history.” Some five hundred civilians died in the bombing a remarkably low number for such a high number of munitions expended. In its own account of the campaignNATO stresses that targets were “carefully sexted” and that “massive effort was made to minimise the impact of the air campaign on the Serb civilian population.”
这需要领导人具备不同的技能——尤其需要领导人对组织的共同目标具有更清晰的视野。在新的一年,如何领导由机器人和人类组成的“团队”的困境将变得更为紧迫。

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

1. Bottoms Up Beer System
Verification and evaluation should be enhanced before publication, Wang said.
Last year, only 930,000 of the 1.39 million qualified finally entered the exam halls.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
156 items - Showing page 1 of 3

About this collection

《老友记》中没有露骨的内容、不干净的台词或是黄段子,但它的幽默感却丝毫不减,为这个电视剧总喜欢裹挟着露骨内容的年代带来一阵清新之风。
On our increasingly human-dominated planet we can still learn much from the lives of other species. The discovery this year that the Greenland shark lives for 400 years, making it the longest-living vertebrate, puts our hectic lives into perspective.

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