Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Since then, Teach First has put 5,000 graduates into schools, working with more than 1m pupils in low-income areas, helping to raise standards in classrooms, particularly London.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
The report also showed regions with a better-developed economy produce more cyberstars, with Beijing, Shanghai, Guangdong, Jiangsu and Zhejiang leading the rankings.
The Amsterdam crisis began when a Dutch group known as the Seppenwolde syndicate made a big, contrarian bet on the shares of East India Company. Those shares had plunged in 1771 mainly because of losses in Bengal, but the company kept paying high dividends and covered up its shortfalls by borrowing money. Convinced that East India shares would quickly rebound, the Seppenwolde group aggressively bought them on margin. But instead of rebounding, the shares fell even further after the company slashed its dividend.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ferreira added that while the entire Brazilian population has suffered during preparations for the World Cup, mostly because of big construction projects that have snarled traffic and extended already long commutes for the poor who live on the outskirts of cities, she feels like only the rich are reaping the benefits of the real World Cup experience.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Trends and targets in antiviral phototherapy
Meanwhile, he was being ferried around the globe to tech conferences, getting introduced to other potential investors. D'Aloisio made a remarkable impression on everyone he crossed paths with. 'He has an eerie maturity,' says Andrew Halls, headmaster of the King's College School in Wimbledon, which D'Aloisio has attended since he was 11. 'He has an extraordinary articulateness in the face of situations that, for me, even as a 54-year-old, might be terrifying.'
Will the Saudi Aramco public offering debut on an international market
With an increase of 7 percent over 2013,total spending on medicines will amount to $1.06trillion in 2014, says the report"The Global Use of Medicines: Outlook through2018" from the IMS Institute for Healthcare Informatics, releasedThursday.
But we are going to get a taste of the new world order when the WTO’s members gather for its biennial ministerial in Buenos Aires in December. It’s unclear, as always, if the WTO will be able to deliver anything of substance. But the real test lies in not having the US leading the way in discussions for the first time in the WTO’s life. Will China step in? The EU? And will India be as minded to block any deal as it has been in the past?
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Track field；hand ball；cycling；track racin；racing cycle；mountain bike race；Bicycle Motocross；horsemanship；football；Beach Volleyball.
金球奖的独特之处在于其同时设置电影和电视奖项。而当地时间周日的这场典礼更是前所未有地模糊了二者的界限，大大褒奖了电视领域这一年来的出众表现。现已剧终的热门电视剧集《绝命毒师》(Breaking Bad)今年首次拿下金球奖，赢得了当晚最热烈的欢呼声。该片荣获剧情类最佳系列剧集奖，片中演员布赖恩?克兰斯顿(Bryan Cranston)荣获剧情类系列剧最佳男演员。
ACE2 as a potential therapeutic target for pandemic COVID-19
Mr Erdogan’s escalation comes in the midst of a vitriolic tit-for-tat between Ankara and The Hague, which began at the weekend after Dutch officials barred Turkish ministers from campaigning in Turkish communities inside the Netherlands.
Diagnostic technologies for COVID-19: a review
Busting through the glass ceiling
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Iron ore imports fell 12.3 per cent by volume in October from the previous month and 4.9 per cent from the same month a year earlier while coal imports were down 21.4 per cent from September and 30.7 per cent from a year earlier, according to Chinese customs data.
Essentially this reform will help the government to focus on performing its due role more effectively instead of overreaching itself, because that will only tie down our businesses, cut government’s efficiencies and even public credibility.
The 2013 World Happiness Report comes on the back of a growing global movement calling for governments and policy makers to reduce their emphasis on achieving economic growth and focus on policies that can improve people's overall well-being.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Please accept our wishes for you and yours for a happy New Year.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
She added that because of economic conditions and anti-immigration sentiment in some Western countries, many Chinese students find it difficult to stay in those countries.
Influenza neuraminidase: A druggable target for natural products
The People’s Bank of China has long intervened in foreign-exchange markets to hedge against excessive volatility. Since August, however, such intervention has expanded from the domestic spot market, which covers daily transactions, to include the offshore renminbi market in Hong Kong, as well as both onshore and offshore futures markets, traders say.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
域名注册公司GoDaddy的总部设在亚利桑那州斯科茨代尔市，该公司5月份在坦佩开工建设新的全球技术中心。GoDaddy公司已经在大凤凰城地区雇佣了2,600名员工，新工厂预计将增加300多个工作岗位。其他在亚利桑那州扩大规模的公司包括领先的技术保障服务公司 Asurion。这家公司在凤凰城开设了新的技术支持中心，将在今年年底招聘500多个职位。能源供应商Direct Energy今年在亚利桑那州坦佩开设了新的呼叫中心，需要招聘300多名员工。
Judge Business School at the University of Cambridge jumps five places to fifth. Not only is it the first time it has broken into the top five, but it is also the first occasion that LBS is not the top-placed UK school in the MBA ranking.
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
德系三巨头：由于奔驰的几款低价产品不可避免地会损害它“要么最好，要么什么都不是”(the best or nothing)的商誉，该公司也开始陷入低迷。而即将推出的新7系轿车则会进一步巩固宝马在美国富人圈中的地位。另外，起价30,795美元的奥迪A3，很可能会使奥迪的销量较2014年增长15%，新款Q7也将进一步提高奥迪的利润。
Alice Schwarzer, who has battled for women’s rights for years, is stunned that “an old-school sexist” like Donald J. Trump could win the United States presidency.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
The best of 2015
Local residents living near the launch sites have complained that the activists are putting their lives at risk by making them potential targets for North Korean retaliation.
Mr Mallaby accepted the award at a dinner in London on November 22, where the guest speaker was Dido Harding, chief executive of TalkTalk, the UK telecoms group.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
While the debate was supposed to be solely about foreign policy, domestic concerns were never far from the surface and the candidates took every opportunity to pivot to their stump speech attacks over the economy and tax. The same was true in the spin room afterwards where both campaign teams dispensed quickly with debate comments and moved instead to analysis of the state of the race in swing states.
These documentaries use the standard tools — archival footage, talking-head interviews, carefully selected musical cues — to write history in the present tense. In the era of Black Lives Matter, the stories of the Black Panthers and the jazz singer and activist Nina Simone could hardly be more relevant. Mr. Nelson and Ms. Garbus tell them beautifully.
Inhibition of SARS coronavirus helicase by bismuth complexes
As fall arrived and school began, D'Aloisio felt immense pressure to deliver for his backers. He needed to whip his algorithm into better shape, so he contracted a team of Israeli coders who specialize in natural language processing. Searching on Google, he found and hired a retired professor living in Thailand who'd written seminal books on the topic. 'He became our main scientist,' says D'Aloisio. 'He now works at Yahoo! in the Sunnyvale office.'
在9月初发布的另一份报告中，世界气象组织(World Meteorological Organization)称，2013年大气中的二氧化碳水平，比工业革命之前的普遍水平高出42%。其他重要的温室气体含量也有所增加，与前工业化时代水平相比，甲烷增加了153%，一氧化二氮增加了21%。
Barack Obama went on the offensive over foreign policy in the third and final presidential debate, repeatedly accusing Mitt Romney of flip-flopping on major international issues but failing to deliver a killer blow to his opponent's resurgent campaign.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
The 5.5-percent increase this year is reasonable given a less anticipated consumer price index (CPI) as well as slower salary and GDP growth, said Jin Weigang, head of the social security research institute under the MOHRSS.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Wishing you peace, joy and happiness through the coming year.在新年来临之际，祝福你平安、快乐、幸福！
It seems that Christmas time is here once again, and it is time again to bring in the New Year. We wish the merriest of Christmas to you and your loved ones, and we wish you happiness and prosperity in the year ahead.又该迎接新的一年了。我们向你及你的亲人们致以最美好的祝福，愿你在新的一年里事业兴旺，幸福美满！
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
This includes McKinsey, the consultancy that kick-started its secretive leadership election process in October with a gathering of more than 500 senior partners at the Grosvenor House Hotel in London. The next stage involves the firm’s 550 senior partners voting on a shortlist of candidates to replace Dominic Barton — the incumbent since 2009 — in January, followed by a run-off between the two most popular candidates in February.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Shipments to China cratered by 14.4 per cent year-on-year to Rmb737.5bn in January. That’s from a 4 per cent drop in December, and versus expectations for a 1.8 per cent rise.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
In October last year North Korean border guards attempted to shoot down some balloons, triggering a brief exchange of heavy machine-gun fire between the two sides.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
在根据真实罪案改编的电影《狐狸猎手》(Foxcatcher)中，以出演喜剧闻名的演员史蒂夫·卡瑞尔(Steve Carell)饰演大富翁约翰·E·杜邦(John E. du Pont)时隐藏在假面具后面。这个造型最突出的就是鸟嘴状鼻子。
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
5. Bank of America Corp.
A savings account had been opened in the boy's name and he used those details when signing up for AdWords.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
This year, the Global 2000 companies hail from 62 countries, up from 46 in our inaugural 2003 ranking. In total, they raked in revenues of $38 trillion and profits of $3 trillion, with assets worth $161 trillion and a market value of $44 trillion.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
The commerce ministry data showing plummeting real estate investment follows an overall 53 per cent rise last year to a record $33bn, according to separate data from JLL, a global realtor.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Next year, the mayor’s affordable housing plan, which calls for building or preserving 200,000 units of affordable housing over the next decade, will begin to take shape. It hinges on a policy that requires developers to build affordable housing in exchange for being allowed to construct taller and denser buildings in neighborhoods rezoned by the city. Developers and housing advocates alike are waiting to see what it will look like once the administration adds muscle and flesh to the bones of the proposal.
During last year's LFW, there were 250 anti-fur protesters, The Guardian reported, and a show in February saw an activist storm the stage at a Mary Katrantzou show.
A cemetery dating back roughly 1,700 yearshas been discovered along part of the Silk Road, a series of ancient trade routes that once connected China to the Roman Empire.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
5. The causes of hair loss and greying are linked, and for the first time, scientists have identified the cells responsible.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
As a result, business investment in key areas such as equipment has been historically weak for a U.S. recovery. A slowly improving jobs picture and rising household wealth could spark a virtuous cycle of stronger consumer spending, increased business confidence and rising investment. If it doesn't, the year could be another letdown.
此次涵盖95个项目（去年为90个）的排行榜中，来自7个国家的9所院校为首次进入榜单。排名第41位的法兰克福金融管理学院(Frankfurt School of Finance & Management)是今年排名最高的新入榜者。这家德国学院拥有性别比例最平衡的项目之一，女性占学员总数的49%。
这是两部后自语核(post-mumblecore)喜剧，讲述自我认知及其边界的故事。布西内斯克的影片是完美的怪人三角，三条边分别是盖·皮尔斯(Guy Pearce)、寇碧·史莫德斯(Cobie Smulders)和凯文·科利根(Kevin Corrigan)，以德克萨斯州奥斯汀怪人们轻松胡混的伪装出现。皮文的影片探索精神病以及日间电视节目的的黑暗疆域。由于克里斯汀·韦格(Kristen Wiig)的精彩演出（她饰演一个名叫爱丽丝·克里格的彩票得主），《欢迎来到我的世界》成了关于美国梦想者的精彩肖像，既令人不安，也鼓舞人心。
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
5. It's a dog's life for the British
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Song of the year: "Over you," Miranda Lambert and Blake Shelton
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
200911/88512.shtmlA love letter to a US college student from the girlfriend who was to become his wife is finally on its way to him - 53 years after it was written in 1958.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Yes, 2014 is an absolute total disaster just waiting to ignite. In 'Doomsday poll: 87% risk of stock crash by year-end' we analyzed 10 major crash warnings since early this year. Since then, more incoming bogies raced across our radar screen. Ticking time bombs from Congress, the Supreme Court, sex, carbon emissions, Big Oil, NSA, IRS, Tea Party austerity. Relentless. Mind-numbing.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Some 88 Chinese universities are included in the Global 400 subjects in the latest QS World University Rankings by Subject, which was released Tuesday by QS Quacquarelli Symonds, a higher education research firm.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Besides exploring the overall ranking, prospective international students can narrow their search by browsing regional and country rankings. These rankings were determined solely by how schools performed in the overall list.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Whether China opens the stock floodgates or not will be a major price-driver in cotton and sugar — and potentially also in corn, soyabean or vegetable oil — markets in 2017, the bank said in its report.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
And, this year, Star Wars found its way onto the list as well, with ‘starwars’ claiming the 16th spot.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Then there were these cautionary tales, where a candidate
Song “Happiness” (Mao A’Min)
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Helsinki-based developer Remedy Entertainment has blurred the line between Hollywood and games with previous incarnations Max Payne and Alan Wake. Now the studio is combining next-generation visuals with the tension and drama of scripted television. Set in the university town of Riverport, Quantum Break puts players in control of Jack Joyce and Beth Wilder, a pair of ordinary people who are given the extraordinary power to manipulate time after an accident that creates a time rift. Time will randomly break down during the game, which causes disasters in the environment that pause, stutter, rewind and freeze. Fans of Max Payne’s bullet time will see new strategies emerge with gunfights involving time-amplified combat as the player fights against the Monarch Corporation. In addition to the virtual storyline, the game features custom live action storytelling that’s personalized based on the decisions one makes.
How do you feel about workingwith Ei Aoki again in Aldnoah?
The Big Bang Theory is not short on geniuses. Not only is the show about highly intelligent scientists, but cast member Mayim Bialik has a Ph.D. in Neuroscience. So it should come as no surprise that the cast would want to show off their intelligence and attention to detail. In Sheldon and Leonard's apartment, there's a large white board. The two roommates use the board frequently for everything from actual work that Leonard or Sheldon has brought home, or to decide whether to eat before or after the new Spider-Man movie.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
6.London's bike hire scheme couldn't be simpler, by the way: just go up to the terminal at any docking station, pay by card and take away one of our so-called "Boris bikes". When you're done with it, simply throw it into the nearest canal. They're disposable!
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
Citing recent figures from the CPB Netherlands Bureau for Policy Analysis, that show global trade in seasonally-adjusted volume terms fell 1.1 per cent between September and October, Mr Leering suggests last year will prove to be the worst year for world trade since 2009.
Length-scale dependence of protein hydration-shell density
Thirty Seconds of Mars, who are fronted by American actor Jared Leto, took home the Best Alternative award, which also saw Lana Del Rey, Lorde, The XX and Imagine.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Overall twenty-eight thousand bombs and other munitions were exploded over Yugoslavia a country the size of Ohio. William Cohen then secretary of defense characterized Allied Force as “the most precise application of airpower in history.” Some five hundred civilians died in the bombing a remarkably low number for such a high number of munitions expended. In its own account of the campaignNATO stresses that targets were “carefully sexted” and that “massive effort was made to minimise the impact of the air campaign on the Serb civilian population.”
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
1. Bottoms Up Beer System
Verification and evaluation should be enhanced before publication, Wang said.
Last year, only 930,000 of the 1.39 million qualified finally entered the exam halls.
About this collection
On our increasingly human-dominated planet we can still learn much from the lives of other species. The discovery this year that the Greenland shark lives for 400 years, making it the longest-living vertebrate, puts our hectic lives into perspective.